Potential of the Allium jesdianum Extract in Suppression of Anxiety and Depression in Mice

Background: Herbal medicine has been widely applied as effective remedy by extensive spectrum of cultures. Psychiatric patients usually don’t accept their disease and also refuse drug therapy. It seems that by herbal remedies we can perform more successful in treatment. Allium jesdianum is an endemic plant of Zagros Mountains of Iran which possessing various applications in traditional food.
Objectives: The aim of this study was to evaluate anxiolytic and antidepressant effect of Allium jesdianum hydro alcoholic extract in mice.
Methods: Antidepressant and anxiolytic effect of Allium jesdianum hydro alcoholic extract were evaluated by elevated plus maze (EPM), open field test (OFT) and force swimming test (FST).
Results: In open field test Allium jesdianum extract significantly decreased number of lines crossed at the doses of 500 mg/kg compared to the control and diazepam group (p<0.05), besides it could significantly increase the number of lines crossed at the doses of 1000 and 2000 mg/kg compared to the control (p<0.01) and fluoxetine groups(p<0.05). In elevated plus maze, Allium jesdianum extract significantly increased time spent (p<0.01) and number of enters in open areas (p<0.05) at the doses 500 and 1000 mg/kg compared to the control group. Moreover it significantly (p<0.01) decreased time spent and number of enters in open areas compared to diazepam group. In forced swimming test, the immobility time for all groups significantly decreased in contrast to the control group (p<0.01).
Conclusion: Results indicated that Allium jesdianum extract has antidepressant effect with stimulator effect in adult male mice, moreover it showed anxiolytic effect.

Author(s): Raziyeh Mousavi, Zahra Haghighi Fashi, Mahsa Hadipour Jahromy* and Rokhsna Rasooli

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