Phytochemical and anti inflammatory evaluation of Alangium lamarckii root extract

The main purpose of present study was to perform phytochemical screening and explore antiinflammatory properties of Alangium lamarckii root extract. The Alangium lamarckii root was studied for phytochemical characteristics and thin layer chromatography (TLC) was studied. The percentage inhibition of carrageenan induced paw oedema was studied in rats. Alangium lamarckii root gave maximum extractive values of 6.4 % w/w with Ethanol and the Loss on Drying value, total Ash value, acid-insoluble ash, water soluble Ash values were within limits. The ethanol extract gave total solid content of 91.96 % w/w. The extract gave positive tests for Phytosterols, Triterpenes, Flavonoids, Carbohydrates and Alkaloids. The extract was free from Glycosides, Saponins, Tannins, Proteins and Amino Acids. The TLC of Alangium lamarckii ethanolic extract was clearly developed with 5% H₂SO₄ in methanol as spraying agent and Chloroform: Methanol (8:2) solvent system. The Alangium lamarckii root gave significant per cent inhibition of the maximal paw Oedema in 6h and very highly significant per cent inhibition of total paw Oedema during 6h. This study revealed that Alangium lamarckii root has good antiinflammatory actions when compared with Diclofenac sodium.

Author(s): Hindustan Abdul Ahad, Yesupadam P, Mallapu Rani E, Suma Padmaja B, Kambagiri Swamy B

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