Physiologically based Pharmacokinetic Modeling of Olanzapine in different Populations

Physiologically based pharmacokinetic (PBPK) modeling permits clinical scientists to reduce practical constraints for clinical trials on patients with special diseases. In this study, simulations were carried out to evaluate the pharmacokinetic parameters of olanzapine using Simcyp® simulator in healthy adults, geriatrics, obese and renal impaired populations A PBPK model was established and validated to predict the pharmacokinetic parameters of olanzapine in different populations. The model used was Advanced, Dissolution, Absorption and Metabolism (ADAM). The PBPK model adequately predicted the pharmacokinetic parameters of olanzapine for the different populations. PBPK modeling could be helpful in the investigation and comparison of the pharmacokinetics in populations with specific disease conditions.

Author(s): Amira m. Ghoneim

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