Photochemical behavior and photobiological action of photosensitive drug Tolbutamide

Irradiation of sulfonamide derived oral antidiabetic drug, tolbutamide (N-[(butylamino) carbonyl]-4- methylbenzenesulfonamide,1) in a phosphate buffered solution under aerobic atmosphere afforded two photoproducts by cleavage of S-N and C (O)-N bonds of urea units. When irradiated with linoleic acid it photoinduced lipid peroxidation. The insignificant decrease in lipid peroxidation test under argon atmosphere indicates that tolbutamide is capable of photosensitizing lipids through a process where oxygen does not play a principal role. Also the efficient inhibition of lipid peroxidation by well established radical scavengers GSH, confirmed the involvement of a type I mechanism

Author(s): Anamika Gupta, Mohd. Rehan Zaheer, Waseem Ahmad and Jawaid Iqbal

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