Pharmacological investigation of methanol extract of Syzigum cuminii seeds and Crateva nurvula bark on the basis of antimicrobial, antioxidant and anti-inflammatory properties

Syzygium cumini (syn. Eugenia jambolana) commonly known as “Jamun” having promising therapeutic value with its various phytoconstituents such as Tannins, Alkaloids, Steroids, Flavanoids, Terpenoids, Fatty acids, Phenols, Minerals, Carbohydrates and Vitamins. Crateva nurvula (Varuna) is also known to be used in Ayurvedic medicine since ancient times in India as it also contains different phytochemical constituents. In the present investigation, seeds of Jamun and bark of Varuna were investigated for their antimicrobial, antioxidant and anti-inflammatory potential. Different solvent extracts of both the plant (s) parts were prepared according to decreasing polarity. The methanol extracts of both the plants were found to be most potent antimicrobial, antioxidant and anti-inflammatory agent in comparison to other solvent extracts. Methanol extracts (200 mg/ml) of Jamun showed maximum potency against Aspergillus niger but showed moderate activity against other pathogens. These extracts also showed predominant in vitro antioxidant activity and in vivo anti-inflammatory activity in carrageenan induced animal models at a dose of 120 mg/kg. Methanol extracts (200 mg/ml) of Varuna showed maximum potency against Bacillus subtilis, Salmonella typhii, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans but showed moderate activity against other pathogenic microorganisms. These extracts were having predominant in vitro antioxidant activity and in vivo anti-inflammatory activity at a dose of 50 mg/kg in carrageenan induced animal models. The methanol extracts of the plants were also screened for their hemolytic activity against sheep erythrocytes but the extracts showed negative hemolysis

Author(s): Abhishek Mathur 1, Reena Purohit2, Deepika Mathur3, GBKS Prasad4 and V. K. Dua1

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