Pharmacological evaluation of ethanolic extract of Kigelia pinnata fruit against ethylene glycol induced urolithiasis in rats

Urolithiasis is one of the third most common afflictions found in humans. The effect of oral administration of ethanolic extract of Kigelia Pinnata fruit on calcium oxalate urolithiasis has been studied in male Wistar albino rats. Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium, magnesium and phosphate. Supplementation with ethanolic extract of Kigelia pinnata fruit significantly reduced the elevated urinary oxalate, uric acid and phosphate. The increased deposition of stone forming constituents in the kidneys of calculogenic rats was also significantly lowered by ethanolic extract of Kigelia pinnata fruit. The results indicate that the ethanolic extract of Kigelia pinnata fruit is endowed with antiurolithic activity.

Author(s): Ravindra Kumar*, Tirath Kumar, Virender Kamboj, Harish Chander

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