Osmotic Delivery of Ziprasidone Hydrochloride

The successful osmotic delivery requires a drug to have moderate aqueous solubility. The objective of the present investigation is to increase the solubility of the ziprasidone hydrochloride in the core of the osmotic pump to cause its own osmotic release. Optimizations of the level of solubilizing agent in the core and to prove that the prepared system follows osmotic mechanism to deliver its content are other objective of this study. The experimental methods involved the preparation of osmotic pump capsule by phase inversion technique, utilizing a hydrophobic plasticizer castor oil. The morphology of the semipermeable was studied by scanning electron microscopy (SEM). The drug was encapsulated in the system with different proportions of PEG-400. The in vitro dissolution kinetics and the optimum level of PEG-400 required for 100% release were determined by regression analysis. The release studies from the optimized formulation were conducted in the mediums of different osmotic pressure. Solubility studies reveled that ziprasidone hydrochloride has poor aqueous solubility. The semi-permeable membrane was shown to have micro porous nature. The amount of the drug released from the osmotic system increased remarkably with increase in the level of PEG-400 in the core. The correlations coefficient of linear relationship suggests that the system follows zero order release kinetics. The release of drug from the developed osmotic pump was inversely proportional to the osmotic pressure of the release medium. Ziprasidone hydrochloride was successfully delivered from the osmotic pump capsule in the presence of PEG-400. Osmotic release was the major mechanism for the release of the drug from the prepared osmotic pump capsule.

Author(s): Chetan S Chauhan, Pushpendra S Naruka and Ravindra K Kamble

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