Nucleo-liposomes as neurotracer for SPECT and anti-cancer drug delivery agents

The Blood-Brain Barrier (BBB) is a major obstacle for drug delivery to the brain. Nucleolipid based liposomes are promising drug delivery systems allowing in vivo tracking using molecular imaging techniques and have proved promising theranostics agents especially for tumors. The blood-brain barrier is the barrier between the cerebral capillary blood and the interstitial fluid of the brain. It is made up of capillary endothelial cells and basement membrane, neuroglial membrane, and glial podocytes, i.e., projections of astrocytes. These 3 components work in synchronicity with one another to limit the entry of various substances into the cerebral blood flow and subsequently the brain parenchyma.

Author(s):  Swastika Mishra

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