Novel spectrophotometric method for the assay of Pitavastatin calcium in pharmaceutical formulations

calcium by using Acidic potassium permanganate is described. The method is based on the reduction of permanganate by pitavastatin in acidic medium, and the unreacted oxidant was measured at 550 nm. The Beer’s law is obeyed in the range of 8.0 – 18.0 μg/ ml for PTV using acidic potassium permanganate reagent. In this method, the amount of permanganate reacted corresponds to the PTV content and the absorbance was found to decrease linearly with the Concentration. The sandells sensitivity, detection limit and quantization limit were also calculated. The optimum reaction conditions and other analytical parameters were evaluated.

Author(s): B. S. Virupaxappa1 , K. H. Shivaprasad1, M. S. Latha2

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