Novel green approaches for synthesis of quinoxaline derivatives

The objective of present research work is to provide green technique for synthesis of quinoxaline derivative. Quinoxaline derivatives are well known in the pharmaceutical industry and have been shown to possess a broad spectrum of biological activities. Highly efficient and simple methods have been described for the synthesis with excellent yields (95-98%). Present synthesis complies with principle of Green chemistry. As part of current studies, we here in reports efficient practical techniques like- sonication (sonochemistry sythesis), UV radiations and simple mortal-pastel method (mechanochemistry). The overall progress of the reaction was monitored by TLC and characterized by IR and NMR. Compared with traditional methods, these methods are more convenient and reactions can be carried out in higher yield, shorter reaction time and milder conditions, without generation of pollution and safer to analyst. The synthesized 2, 3- diphenyle quinoxaline was confirmed by physical constant and spectroscopic studies.Low cost, simple to run, maximum efficiency are some advantages of these techniques. Compared with traditional methods, these methods are more convenient and reactions can be carried out in higher yield, shorter reaction time and milder conditions, without generation of pollution and safer to analyst. From these features present methods can be correlated for safer and efficient synthesis of other products

Author(s): Atul R. Bendale 1, Darsheen Kotak2, D. P. Damahe2, Sushil P. Narkhede1, Anil G. Jadhav2and G. Vidyasagar3

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