Nootropic activity of n-butanolic fraction of methanolic extract of leaves of Ziziphus mauritiana Lam. in mice

In the present study, we investigated the effects of n-butanolic fraction of methanolic extract of leaves of Ziziphus mauritiana, Lam (BZM 10, 25 and 50 mg/kg) on learning and memory in mice using Elevated Plus Maze, Passive avoidance Paradigm and Object recognition test. Piracetam was used as standard drug. The acute toxicity study shows no mortality up to BZM 2000 mg/kg. Decrease in the transfer latency reported with the treatment of BZM on the elevated plus maze after 24 hrs. and on day-7 and it expressed as inflexion ratio (IR). Significant increase in step down latency was observed on passive avoidance paradigm. The object recognition test report increase in Recognition Index (RI) indicates its nootropic effect. No neurotoxicity observed with all dosage using rota-rod method. BZM 25 mg/kg also antagonises the amnesia produced by scopolamine and hence indicates involvement of central cholinergic mechanism in its effect. Hence, the present study proved nootropic effect of n-butanolic fraction of methanolic extract of leaves of Ziziphus mauritiana.

Author(s): Khan Dureshahwar, Mohammed Mubashir, Hemant D. Une, Galib I. Hundekari and M. H. Dehghan

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