Nasal drug delivery: An approach of drug delivery through nasal route

Over the last few decades transmucosal nasal drug delivery as a non-invasive route has occupied an important place in the field of drug delivery technology. This is due to high vascularity, large surface area, the avoidance of hepatic first-pass metabolism, gut wall metabolism and/or destruction in gastrointestinal tract. Since nasal mucosa offer several benefits for target drug delivery, a wide variety of therapeutic compounds may be administered intranasally for topical, systemic and central nervous system action. In this review, we focus on the different aspects of nasal anatomy, and histology, and the different factors that must be considered during the development of formulation for nasal delivery. We also outlined the different methods has been used to study the nasal absorption in rats.

Author(s): Sanjay Dey, Beduin Mahanti, Bhasakar Mazumder, Ananya Malgope and Sandeepan Dasgupta

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