Microwave-Assisted Dry Synthesis of 2-Amino-1H-imidazoles Supported by a Natural Clay

A new and efficient solid natural clay supported microwave-assisted protocol for the preparation of 2-amino-imidazole was developed. Starting from cheap commodities O-methyl-iso-urea and acetals or ketals of α–amino carbonyl compounds the desired product is isolated through a very simple work-up in a good yield. Use of solid acid clay catalyst instead of strong mineral acids under solvent-free condition is a major significance of this method. This new procedure overcomes several technical and environmental problems of the traditional approaches to this molecule and is therefore very attractive for large-scale preparation

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