Metallonuclease activity of copper(II) complexes containing benzimidazolyl terpyridine

Mononuclear copper(II) complexes [Cu(bitpy)2](ClO4)2 (1) and [Cu(bitpy)(Cl)](Cl) (2) (where bitpy = 4'- (benzimidazolyl)-2,2':6',2''-terpyridine) have been synthesized. Physico-chemical techniques like elemental analysis, ESI-MS, UV–Visible, Infra red and EPR spectroscopic techniques were employed to characterize the synthesized complexes. The complexes are one-electron paramagnetic and exhibit quasi-reversible cyclic voltammetric response at 100 mVs-1 in DMSO-TBAP for the CuII/CuI couple. Oxidative DNA cleavage of the complexes has also been studied. Both the complexes however successfully promoted an oxidative cleavage of plasmid DNA, producing single strand break.

Author(s): R. Elayaperumal1 and P. Dharmalingam

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