Loneliness and emptiness with reorientation syndrome after TBI

The brain in TBI in one second suffers damage mostly at all areas and the pattern of lesions reflect the forces on the scull in the moment of the trauma, which results in different symptoms after every single trauma.  The common problem for the TB Injured is to overcome the sudden change of emotions and to accept the new situation with memories in the body corresponding to the time before the accident.  Method:  TB Injured members of the Austrian Association of TBI were interviewed about the situation after TBI. Results: The change in life affects personnel capacities, the position in the families and at work, the financial/social situation and it results Mechanism of action has been defined between DNA topoisomerase II and the series of bicyclic compounds3 which were examined in detail using molecular modeling studies such as molecular docking and pharmacophore analysis performed by using Discovery Studio4 and LigandScout5. This study also provides a model to design novel and more potent anticancer agents as human topoisomerase II poisons in a change of key persons in life.  The burden of change is more important, if the person previously was strong, body oriented and had to define himself through a hierarchic system, as e.g. military organisations represent.  The TB Injured is in an inside/outside empty space and has to reorient himself with reduced brain capacity.  Reorientation Syndrome affects also the caregivers:  Conclusions: Most persons, injured and families feel left alone after TBI.  Caregivers and case managers are not skilled enough to deal with emptiness, reorientation, mourning process and the issue of responsibilities resulting through medical, therapeutic and social consequences after TBI.  The Reorientation Syndrome is a considerable condition after each TBI that has to be respected to be able to help TB Injures and the families to be reintegrated after TBI.

Author(s): N. Steinhoff

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