Liver Changes Due To Chronic Fructose Intake Might Be Attenuated With A Return To The Control Diet

Aims: Nowadays, there has been much concern about the role of dietary fructose in the development of metabolic diseases. This study aimed to evaluate if, the effects of fructose intake in the mouse liver are reversible when the consumption is suspended.

Methods: C57/BL6 mice were fed for 16 weeks with the diets: control diet (C group, standard chow for 16 weeks); high-fructose diet of 25% (F25 group); high-fructose diet of 50% (F50 group); F25 for 8 weeks plus control diet for an additional 8 weeks (F25+C group); F50 for 8 weeks plus control diet for an additional 8 weeks (F50+C group).

Results: The glucose intolerance observed in both groups F25 and F50, was reduced after returning to the control diet. In general, after a period of consuming fructose at all the concentrations studied, we measured raised levels of leptin, resistin, IL-6, plasmatic lipids, alanine aminotransferase, and aspartate aminotransferase. However, these levels diminished when the animals switched to the control diet. Also, the increased liver steatosis because of fructose could be controlled after returning to the control diet.

Conclusion: The consumption of fructose at different concentrations is linked to metabolic impairment, like glucose intolerance and decreased insulin sensitivity, and augmented proinflammatory cytokines, which continues after the return to the control diet.

Author(s): Pamela Carvallo, Eugenia Carvallo, Sandra Barbosa-da-Silva, Carlos A Mandarim-de-Lacerda and Mariano del Sol

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