Investigating Antiuroliathiatic Potential of Phyllanthus niruri L. A Member of the Family Euphorbiaceae

The inhibition of in-vitro calcium-oxalate crystal formation by Phyllanthus niruri L. extract was investigated by different methods i.e. nucleation assay and synthetic urine assay. In nucleation assay, the aim was to evaluate the effectiveness of different concentrations of the extract on calcium oxalate crystallization in vitro while in synthetic urine method the percentage inhibition and growth of the calcium oxalate monohydrate crystals from synthetic urine at different % concentrations of extract was investigated. Results revealed that in both the assay % inhibition for calcium oxalate crystal formation was found to be directly proportional to the increase in concentration of the plant extract with maximum inhibition of 61.97% ± 0.78 at 1000mg/ml in nucleation assay, while in synthetic urine assay maximum inhibition was 58.62 ± 0.02 %at 100% concentration of extract. Thus, the extract showed potent antilithic ability in both the assays studied.

Author(s): Kumkum Agarwal and Ranjana Varma

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