Interferon-γ Induced Human Guanylate Binding Protein-2: A Path Less
Discovered

Interferon–gamma–inducible large GTPases, Guanylate Binding Proteins (GBPs) have recently emerged as a central player in host defense against viral, bacterial, and protozoan infections. Most of the studies encompass biochemical and biological functions of the human GBP-1 (hGBP-1). hGBP-2, a close homolog of hGBP-1, in recent times has gained attention due to its association with several carcinomas. The present mini-review provides a detailed understanding of the molecular mechanism of GTPase activity of this protein and also illustrates how it differs from hGBP-1 with respect to GMP formation. We also exchange our views on probable reasons for lower GMP formation in hGBP-2, which may have implications in its biological functions.

Author(s): Apurba Kumar Sau* and Sudeepa Rajan

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