Increased anticancer activity of curcumin-Zn (II) complex by species sensitive method

The complexing ability of anticancer drug curcumin with Zn(II) was studied in aqueous media with in the pH 6.1±0.1 by means of polarography, amperometry and spectrophotometry. The polarogram of acidic media indicated that a chemical reaction has taken place between curcumin and Zn (II) shows that formation of complexes. The complexes behavior of curcumin with Zn (II), both in solid and liquid phase has been studied by polarography, amperometry and spectrophotometry. Curcumin produce a well defines direct current polarogram and differential pulse polarogram in 0.1 M ammonium tartrate (supporting electrolyte) at pH 6.1±0.1. The stoichiometry of Zn(II) - curcumin complex is 1: 1. Anticancer studies on the drug and its metal complex have been performed against sarcoma cells (In Vitro). The observed results revealed the complex to be more potent in anticancer activity as compared to the parent drug

Author(s): Garima Modi

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