In Vivo Topical Wound Healing Activity of Punica Granatum Peel Extract on Rats

Punica granatum is a well-known fruit for its antioxidant, hepatoprotective, anticancer, antibacterial potential. The methanolic extract of Punica granatum, in the form of an ointment with two different concentrations (10% and 15% w/w ointment of extract in simple ointment base) was evaluated for wound healing potential in an excision wound model in rats. The results were comparable to standard drug Nitrofurazone ointment. It was observed that the wound contracting abilities of 10% and 15% extract ointments (97.8%, 98.4%) were significantly (P < 0.05) greater than that of the control. The wound closure time was less and the percentage of wound contraction was much more with the 15%w/w extract ointment treated group. On 18th day 100% contraction was observed which was almost similar to that of the nitrofurazone ointment group. 10%w/w extract ointment group of animals showed significant wound contraction from the 18th day onwards and achieved 100% with the wound closure time of 20th days. Both concentrations of the methanolic extract of Punica granatum ointment showed significant responses when compared with the control group. Thus methanolic extract of Punica granatum proves to be a potential wound healing agent.

Author(s): NITIN NEMA, SAURABH ARJARIYA, SM BAIRAGI, MEGHA JHA, MD KHARYA

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