In vivo Evaluation of Peripheral Analgesic and Diarrhea Retardation Effects of Crude Methanolic Extracts from Diverse Potential Spice Cinnamomum zeylanicum L. Barks on Swiss Albino Mice

The crude methanolic extracts from the bark of Cinnamomum zeylanicum (C. zeylanicum) (Family: Lauraceae) were carried out for the evaluation of peripheral analgesic activity and anti-diarrheal activity in vivo bioassays using a group of Swiss Albino mice. Two different doses containing 400 mg/kg and 200 mg/kg with respect to the weight of the test animals were administered in both the cases for the assessment of action in comparison with the standards. In the estimation of analgesic effect peripherally, both the extracts of C. zeylanicum exhibited extremely significant pain relieving action with percent inhibition of licking responses of 63.89% at 400 mg/kg and 66.67% at 200 mg/kg close to the value of standard Acetyl Salicylic Acid with 75% inhibition of response induced by Acetic Acid at a dose of 0.1 ml/kg of body weight to each mouse. The bark extracts of C. zeylanicum at lower dose of 200 mg/kg showed extremely statistically significant anti-diarrheal activity with 68.18% reduction of diarrhea compared to the standard loperamide 59.09% in castor oil induced antidiarrheal assay protocol.

Author(s): Islam S Md, Mamun M Md, Das P, Spriha ES, Sohel D Md and Kawsar H Md

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