Hypoglycemic Activity of Murraya koenigii (Meethaneem) Leaves Collected from Udaipur, Rajasthan (India)

Introduction: Medicinal plants are being used in the traditional systems of medicine in many parts of the world, especially in rural communities for diverse types of ailments. Diabetes mellitus is one of the extreme common chronic diseases. Many synthetic drugs are used to control hyperglycaemia. However, due to host resistance and other adverse effects of these compounds this becomes essential to find out the natural source to combat with the disease.
Objective: The main objective of current study was to evaluate the hypoglycaemic activity of Murraya koenigii (Meethaneem; Rutaceae).
Method: Leaves collected from Udaipur, Rajasthan region in the month of October were evaluated for hypoglycemic activity. Male wistar rat was used as experimental animal. Diabetes was induced by an intra-peritoneal (i.p.) injection of Streptozotocin. Animals with blood glucose>200mg % were selected and used for the study. Single dose of aqueous slurry of dried leaves powder (250mg/Kg) of Murraya koenigii were administered to selected animals for evaluation.
Result: Murraya koenigii (Meethaneem) leaves slurry exhibited a significant hypoglycaemic activity on fourth hours of dosing, which reduced the glucose level up to 56% that is more effective than standard drug Glibenclamide (49%) and statistically significant (<0.05).
Conclusion: The novelty of the work done is embedded in collection of data of hypoglycaemic activity of Murraya koenigii (Meethaneem) leaves collected from Udaipur, Rajasthan, India in the month of October, which showed a remarkable potential. The results was comparable to standard compound (Glibenclamide).

Author(s): Pratibha Chaturvedi*, Abhay Chowdhary

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