Hydro-alcoholic Root Extracts of Ziziphus abyssinica is Effective in Diabetes Nephropathy and Diabetic Wound

Background: This study evaluated the potential of Ziziphus abysinnica root extract in managing type 2 diabetes mellitus (T2DM) and its associated complication, diabetic
nephropathy, and impaired wound healing.

Methodology: Blood glucose concentrations were measured daily for 14 days after daily administrations of Ziziphus abysinnica (30, 100, and 300 mg/kg, p.o), metformin (300 mg/kg, p.o) as a positive control, and normal saline as negative control before diabetes induction using a single dose of streptozotocin (60 mg/kg, i.p) and nicotinamide (120 mg/kg, i.p).

Results: Generally, the percentage of blood glucose levels were analysed following administration of drugs was found to be dose-dependent. The highest dose of Z. abysinnica (300 mg/kg) had a higher percentage reduction in blood glucose concentration when compared to metformin (300 mg/kg). Histopathological analysis was performed on the kidneys following administration with Ziziphus abysinnica in diabetic rats. The lowest dose group administered with (30 mg/kg) demonstrated minimal to moderate pathological changes to the kidney architecture. In contrast, the 100 mg/kg and 300 mg/kg dose groups displayed maximal toxic pathologic changes to the kidney nephrons. Conclusion: Overall, our study has demonstrated the antidiabetic potential of Ziziphus abysinnica, suggesting its possible therapeutic benefit in diabetic nephropathy.

Author(s): Samuel A. Akwetey, Douglas B. Aidoo, Wisdom Ahlidja, Joseph M. Acquah, Joshua F. Agyei, Desmond Bakoji and Portia A. Okyir

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