Hepatitis B virus genotypes/subgenotypes: Epidemiology, pathogenicity and response to therapies

Hepatitis B virus has been divided into ten genotypes, A-J, and in several respective subgenotypes on the basis of phylogenetic analysis of whole genome. Different geographical region has been dominated by different genotypes. It has been proposed by many studies that different genotypes have been found to have different pathogenic behavior and respond differentially to different therapies. Similarly, several other studies correlate the differential clinical outcomes of HBV-induced liver disease with respect to genotypes. So, in the present review we try to club as maximum as possible information regarding the Hepatitis B virus genotypes/subgenotypes epidemiology, characteristic pathogenic behavior and response to various interferon’s and nucleos(t)ides analogues.

Author(s): Vikas Pahal*, Jasbir Singh† and Krishan Swaroop Dadhich*

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