Heparin in Dialysis

In the 1930-ies, Strassmann and Hahn had done research for the nuclear decay of Uranium 238. The nuclear decay followed to an exponential function of natural logarithm. In the 1970ies, several medical doctors with facilities of mathematics while working in Nephrology, had developed the new discipline of Pharmacokinetics. Two of them were Dettli and Baethke. They recognized the same principle of decay in the drug elimination, the exponential function. They also introduced nearly the term, the biological half-life-time, in order to characterize the elimination of a drug

Author(s): Thomas Ryzlewicz

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