Hepactoprotective effect of Piliostigma thonningii leaves on male wistar albino rats

Piliostigma thonningii is a medicinal plant with proven anti-malarial, anticough, antisnake, anti-inflammatory and antihelmintic potentials. This present study is aimed at ascertaining the effect of ethanol extract of P. thonningii leaf on liver function indices of albino rats. Twenty (20) male wistar albino rats ranging from180-200g were randomly assigned into group (A-D) of five animals each. Groups(B-D) were administered 1ml of ethanol extract via oral route corresponding to50, 100 and 200mg/Kg/body weight, while group A (control) received 1mlof distilled water orally. Rats in all groups were sacrificed 24hours after the experimental periods of 21days of oral administration of the extract. The extract significantly (p<0.05) increased serum Albumin, Globulin, Total protein and Total bilirubin concentration when compared with the control. The serum AST, ALT and GGT showed a significant decrease while serum ALP produced a significant (p<0.05) increase when compared with the control. Also the extract of p. thonningii produced a significant reduction (p<0.05) on liver AST, ALP and GGT when compared with the control. The alterations by the results are manifestation of its hepato protective effect.

Author(s): 1Dasofunjo K, Nwodo O. F. C, Yakubu O. E, Ejoba R, Ukpanukpong R. U, Ipav S. S, Ugwu M. N, Okafor A. I. and Girgi S. L

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