Green Tea Extract Ameliorates Ethanol Induced Liver Injury in Albino Rats

In the present study, it was try to investigate the effects of green tea on some biochemical parameters of male albino rats with ethanol toxicity. All rats were divided into 4groups, Group 1 (controls) and group 2 (ethanol control) remaining 2 groups were treated with ethanol and green tea extract for 30 days. The results showed significant elevation in the level of ACP, sugar (P<0.001), and Bilirubin (P<0.005) where as liver weight Showed no significant elevation with ethanol as compared to normal. These changes in all parameters indicated liver injury and hepatomegaly due to the enhancement in the ROS which causes decrease in antioxidants of body defense system. The green tea extract with ethanol treatment was able to restore these changes at various levels of significance comparing with the control group of rats. These data suggested that the green tea exerts improvement in liver function by preventing the production of reactive oxygen species (ROS) and enhancing the antioxidant defense system capacity. Thus green tea extract has protective effects against ethanol toxicity.

Author(s): Poonam Lodhi, Neeraj Tandan, Neera Singh, Divyansh Kumar

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