Genome Wide Identification and Characterization of BRCA1 Genes inHomo Sapiens

Breast cancer is the most prevalent cancer in the world. Approximately one in every nine Pakistani women is likely to suffer from breast cancer showing an incidence rate of 50/100,000 and breast cancer is growing at an alarming rate in Pakistan. The main causative element remains unknown yet primary risk factors identified are sex, age, parity, genetics, lack of child bearing, breast feeding, higher hormonal levels individual lifestyle etc. In Indian and Asian women as compared with western women. Knowledge of this factor emphasizes the need to modify the timing of modalities of detection of early carcinoma and its management inherited mutations in the breast cancer susceptibility gene 1 (BRCA1) (MIM 113705) and breast cancer susceptibility gene 2 (BRCA2) (MIM 600185) are associated with a high risk of developing breast cancers in females of different age and ethnic group.

Author(s): Muhammad Waqar Mazhar, Hira Tahir, Fatima Mazhar, Saira Saif, Javaria Mahmood, Nibras and Mudasra Skindar

Abstract | Full-Text | PDF

Share This Article