Formulation of azithromycin and chloroquine phosphate FDT by enhancing their solubility using cyclodextrins complex

The main aim of the present study was to evaluate Azithromycin and Chloroquine drug in combination therapy used in the treatment of Chloroquine resistant malaria by increasing the solubility and dissolution rate of Azithromycin and Chloroquine phosphate by complexation techniques using β-Cyclodextrins with varying concentrations and after selection of proper ratio with carries an attempt was made to develop and evaluate fast dissolving tablet of Azithromycin Chloroquine phosphate using synthetic super disintegrates. The main objective of the present investigation is to explore the possibility of improving low solubility and hence dissolution profile. Fast dissolving drug delivery system of Azithromycin and Chloroquine phosphate with an aim of improving dissolution profile, patient compliance better therapeutic efficacy, less side effect and reduce dosage regimen with less toxicity for treatment for many acute and chronic disease. Evaluation of solubility profile, the pre and post compression parameters of the tablets, drug content, % drug release, drug content of all the formulations were with its range and the disintegration time 19-29 Sec. The dissolution study shows that the formulation containing β- Cyclodextrins from Azithromycin FDT shows 81.55 to 91.61 at the end of 45 min and Chloroquin phosphate shows 80.0 to 90.0% drug release at the end of 45 min.

Author(s): Pentewar R. S., KshirsagarNilesh, SayyedSarfaraz Ali and Kulkarni Keshav

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