Formulation and Evaluation of Taste Masked Doxycycline HCl Medicated Jelly

Aim: The aim of present study was to formulate and evaluate the taste mask Doxycycline HCl medicated oral jelly by making complex with β cyclodextrin.

Methods: The slurry was prepared by using glucose 53%, sugar 34%, gelatin 25% and sorbitol 2.52%. All physicochemical characteristics like viscosity, homogeneity and viscosity, pH, synersis, palatability and taste were performed on this medicated jelly.

Results: In vitro dissolution studies were performed on this formulation in artificial saliva which showed maximum 99.3% drug release within 20 min. The release pattern of this medicated jelly followed the first order release kinetics. Stability study at 40 ± 5ºC was performed for three months which has shown the satisfactory result.

Conclusion: Doxycycline HCl is absorbed from buccal mucosa as well as from GIT. The chewing has shown drug release of greater than 90%. Thus it can be said that oral medicated jelly of Doxycycline HCl was made successfully.

Author(s): Syed Nisar Hussain Shah, Shahnila Aslam, Hina Javed*, Asma Nawaz, Kashif Kamboh and Muhammad Mohsin Javaid

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