Formulation and evaluation of solid matrix tablets of repaglinide

An appropriately designed controlled-release drug delivery system can be a major advance towards solving problems concerning the targeting of a drug to a specific organ or tissue and controlling the rate of drug delivery to the target tissue. Matrix tablets are an interesting option when developing an oral controlled release formulation. The aim of this study is to develop a once-daily sustained release matrix tablet of Repaglinide using sodium alginate as release controlling factor. In order to achieve required sustained release profile tablets were compressed using sodium CMC, sodium alginate, Magnesium Stearate, and PVP. Six different formulation of Repaglinide were prepared by using different ratio of drug: polymer. The tablet was characterized by hardness, wetting time, weight variation and In Vitro Drug Release which shows the satisfactory result. All batches of solid matrix tablets were satisfactory in terms of dissolution profile. The batches of all formulations, MT5 batch [Sodium CMC With drug (1:3)] showed more release than the other concentration and better results. The MT5 batch of Solid matrix tablets was found to be 96.0 % drug release in 300 minutes

Author(s): Jitender Joshi, Lata Bhakuni and Sachin Kumar

Abstract | PDF

Share This Article