Formulation and Evaluation of Ibuprofen Tablets Using Gum of Anacardium occidentale as Binding Agent

Anacardiumgum derived from the edible seeds of Anacardiumoccidantale(family Anacardiaceae) was evaluated for its binding properties at a concentration of 5 % w/w and 10% w/w in Ibuprofen tablets with official starch as a control. A comparative analysis showed that the granules bound with Anacardiumgum were relatively bigger and harder than the ones obtained with starch gum. The hardness, disintegration time and dissolution rate increased with increase in concentration of Anacardiumgum. Tablets containing 10% w/w of Anacardiumgum had a binding capacity approximately twice that of starch with a dissolution rate of 58.5% after 30 min. The results obtained suggest that Anacardiumgum possesses potential as a commercial binding agent.

Author(s): Suja C Jayan, Navaneet Krishna Manoj, Neethu Chacko, and Sheena.K.K

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