Formulation and evaluation of fast dissolving tablet of Ramipril

This research was to formulation and evaluation of fast dissolving tablets of Ramipril using direct compression technique (effervescent) with sodium bicarbonate, mannitol, polyvinylpyrrolidone, citric acid. Eight different formulation of Ramipril were prepared by using different ratio of NAHCO3: MANNITOL by direct compression method. The tablet was characterized by hardness, wetting time, weight variation, water Absorption Ratio, In Vitro Drug Release. All batches of fast dissolving tablets were satisfactory in terms of dissolution profile. The hardness, wetting time, water absorption ratio and wetting time were also shows the satisfactory result. The batches of all formulations, FDT4 batch with sodium bicarbonate: mannitol (1:3) showed more release than the other concentration and better results. The FDT4 batch of fast dissolving tablets was found to be 97.56 % drug release in 30 minutes. The FDT4 was the best of all eight formulations of Fast Dissolving Tablets of Ramipril. Bioavailability of Ramipril can be increased by formulating it as a Fast Dissolving Tablet.

Author(s): Harish Chander, Sachin Kumar and Bineeta Bhatt

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