Formulation and characterization of albendazole chewable tablets

The objective of the present study was to develop an effective formulation of Albendazole chewable tablets.Albendazole (ABZ) is a benzimidazole derivative that has been widely used in the treatment of worm infestations in both humans and animals. Albendazole chewable tablets were prepared by wet granulation method using two superdisintegrants such as croscarmellose sodium and sodium starch glycolate. A total of eight formulations were prepared and the granules were evaluated for precompression parameters such as angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The formulated tablets were evaluated for diameter, thickness, hardness, weight variation, friability, disintegration and drug content. The results showed that all the physical parameters were within the acceptable limits. IR spectral studies revealed that there was no interaction between the drug and excipients. The in vitro release study of formulation F8 showed 81.03%drug release at the end of 30 min. The stability studies for the formulation F8 showed no significant change in disintegration time, drug content and percentage drug release after stored at 40o±2oC/75±5%RH for a period of 30 days. Hence the study concludes that formulation F8 showed better characteristics of chewable tablet.

Author(s): V. Anusha, S. Palanichamy, M. Sugumar, M. Rajesh, N. Parasakthi, T. Godwin Raja Das, P. Ramasubramaniyan and A. Thanga Thirupathi

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