Ex-vivo exposure to a small molecule, enhances migration and homing of murine Hematopoietic stem and progenitor cells

Acute Radiation Syndrome (ARS) or sickness occurs after a wholebody exposure to a high dose of ionising radiation over a short time frame. This type of acute exposure is often associated with accidental exposure as in the case of atomic bomb survivors, nuclear radiation accident victims and sometimes planned exposure like radiation therapy patients. Based on the differences in the cellular sensitivity to Ionising radiation, ARS is broadly divided into hematopoietic (Bone marrow syndrome), gastrointestinal, and neurovascular syndrome. Thus, the amount of radiation dose absorbed by the body, determines the severity of symptoms and the type of ARS. Additionally, ARS manifest in 4 stages, namley Prodromal, Latent, Manifest illness, Recovery or death stage.

Author(s): Anoushka Khanna

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