Evaluation of ulcer protective effects of Ocimum sanctum and Zingiber officinalis as herbo-formulation for aspirin induced ulcerations in Albino rats

Peptic ulcer disease is a serious GIT disorder that requires well-targeted strategy. A number of drugs including proton pump inhibitors (PPIs) & histamine H2 receptor antagonists are available for treatment of peptic ulcer. Clinical evaluations of their drugs has shown incidence of side effect. The present study includes evaluation of herbo-formulation consisting of Ocimum sanctum and Zingiber officinalis as ulcer protective in albino wistar rats. The alcoholic extract of ocimum, ginger (100 mg), combination of both (75mg/kg, 100mg/kg), ranitidine 10mg/kg & CMC 1% per oral were used. After ulcer induction with aspirin (200 mg/kg p.o.) the number, scoring area & finally Ulcer index were accessed. We found that extract decreases the incidence of ulcers. The herboformulation showed dose-dependent ulcer protective effect (62.00-67.20%) in aspirin induced ulcer. Ocimum and Zingiber extract reduced the ulcer index with significant per cent protection (60.00% and 34.40% respectively). The herboformulation at a dose of 100mg/kg found to be effective having percent protection (67.20%) as compared to the dose 75 mg/kg (62.00%) & significantly reduce free, total acidity & pepsin activity.

Author(s): Harshal Fegade, Yaseen Gigani, Amit Vekaria, Sagar Bhavsar, Sudhakar Jadhav, Nikku Yadav

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