Evaluation of Gastric Anti-Ulcer Potency of Ethanolic Extract of Sesbania Grandiflora Linn Leaves in Experimental Animals

Objective: To evaluate gastric anti-ulcer potency of ethanolic extract of Sesbania grandiflora Linn (EESG) (Fabaceae) leaves in experimental animals.
Methods: EESG was investigated in pylorous ligation and ethanol induced ulcer models in Wister rats. In both models ulcer index was determined as common parameters. The extract was ingested orally at doses of 250 and 500 mg/kg to the ulcer induced rats for determining the potency of ulcer inhibition.
Results: The extract (250 and 500 mg/kg) showed significant (P<0.05) reduction in gastric volume and ulcer index as compared to the control in both of the ulcer models.
Conclusions: It can be concluded that EESG possesses anti-ulcer effect as well as ulcer healing properties, which might be due to antisecretory properties.

Author(s): Dayananda Bhoumik, Abera Hadgu Berhe and Arunabha Mallik

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