Evaluation of anticataract potential of Waltheria indica in albino rats

Waltheria indica L., a member of Sterculiaceae family, is widely used as an Antioxidant traditionally to treat a variety of infections in humans. The present study was carried out to evaluate the Anticataract activity of Waltheria indica. The ability of Waltheria indica to tweak the biochemical parameters were explored in this study. Naphthalene cataract was actuated in rats by sustaining with naphthalene 1g/kg for 28 days. Rats in the test gathering were sustained orally with 100mg/kg and 200mg/kg of Waltheria indica every day for 28days and rats in the control gathering just received the vehicle. In this study, morphological assessment demonstrated that Naphthalene treated gathering demonstrates increased opacities when contrasted with normal gathering. A fall in the glutathione level and a climb in the Malondialdehyde levels were seen in control rather than normal lenses. Administration of Waltheria indica significantly restored the glutathione and Malondialdehyde levels. SOD, Catalase and Glutathione S transferase levels were significantly restored to normal levels (p<0.05 and p<0.01 respectively). Oral administration of Waltheria indica significantly delayed the onset and progression of cataract in Naphthalene induced cataract. The Anticataract potential is evident from the slit lamp microscopic images. It can be said that the leaves Waltheria indica protected the lens against naphthalene damage which may be due its antioxidant activity.

Author(s): Mohammed Azharuddin, Shaik Abdul Rahman, Mohammed Ibrahim Ahmed1, Syed Baquer Mahmood and Mohammed Atif*

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