Research in recent years has indicated integrated role played by neuro-immuno-endocrine interactions in maintaining homeostasis and deranged cross talk in these intricately complicated systems in development of various complex chronic illnesses, autoimmune disorders. The most convincing evidence of importance of this interactions is the fact that immune cells express hormone receptors (which may be present under basal conditions like or may be expressed on stimulation), express cytokines which act on nervous system as well as on endocrine glands and in addition exert autocrine and paracrine effects. In turn endocrine glands express receptors for the cytokines released by immune cells. Thus there exists bidirectional communication between these systems [1].