Electrotransference of the mouse growth hormone gene associated with the administration of mesenchymal stem cells, in a murine model of osteogenesis imperfect

Osteogenesis imperfecta (OI) is an inherited connective tissue sickness characterized via fragility, deformity and
low bone density, as well as by other scientific manifestations. Type I OI is the mildest and most commonplace form of
the disease, caused by mutation inside the COL1A1 gene, resulting within the production of handiest ~50% of everyday
collagen. The corresponding animal model is the oim mouse, supplying a phenotype very just like human kind I OI. We
intention, for the first time, at comparing the electrotransference of mouse increase hormone (mGH) gene, encoding
a protein that already confirmed therapeutic effects, collectively with the administration of murine mesenchymal stem
cells (MSCs), for enhancing heterozygous oim mice phenotype

Author(s): Alissandra de Moura Gomes

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