DNA Repair and Colon Cancer Chemotherapy

Dicer is that the critical part of the RNA impedance pathway. In 2008, our gathering announced that Dicer knockdown prompted DNA damage aggregation in mammalian cells. Accordingly, two gatherings showed that Dicer-subordinate little RNAs delivered from the groupings nearby DNA twofold strand break (DSB) locales were fundamental for homologous recombination-interceded DSB fix. As of late, we observed that Dicer is related with SIRT7 and is expected for DNA harm instigated chromatin unwinding by advancing H3K18Ac DE acetylation, diminished Dicer articulation restrained non-homologous end joining by forestalling chromatin unwinding at DSB locales. Additionally, we showed that Dicer knockdown and overexpression expanded and diminished separately, the chemo sensitivity of colon malignant growth cells, and that Dicer protein articulation in colon disease tissues of patients was straightforwardly connected with chemo resistance. Our discoveries recommend that control of Dicer articulation might further develop chemotherapy impacts for patients with colon disease, and perhaps different malignant growths

Author(s): Roma Keth

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