Development of validated UV spectroscopic method to estimate dexibuprofen from its formulation by hydrotrophy technique

The present study was aimed to develop a hydrotrophy technique to increase the solubility of poorly water soluble drug. This technique is used to estimate the amount of Dexibuprofen in bulk drug and tablets by spectrophotometric method by using tri sodium citrate as hydrotropic agent. Beer’s law was obeyed in the concentration range of 2- 20μg/ml and showed maximum absorbance at 231nm. The solubility of Dexibuprofen in distilled water was found to be very less and then by adding hydrotropic agent solubility was increased as compared with distilled water. The analysis of tablets indicated good correlation between estimated and label claim. The LOD and LOQ of Dexibuprofen was found to be 0.0544μg/ml and 0.169μg/ml respectively indicated good sensitivity of proposed method. The percentage recovery was found to be 99.18%-99.607%. The proposed method is new, simple, accurate, non-toxic and precise method that can be successfully employed for estimation of drugs in routine analysis of tablets

Author(s): S. Vijayaraj , V. Suresh, V. Sarath Kumar and A. Abdul Razak

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