Development of chronomodulated drug delivery system of Pravastatin sodium for the treatment of hypercholesterolemia

An attempt has been tried to develop a chronomodulated drug delivery of pravastatin sodium, which can be taken at bed time (10 pm) and capable of releasing the drug between night and early morning hours after predetermine time delay (4 h), when free cholesterol levels are more prevalent, can prevent various heart diseases like atherosclerosis, stroke, angina and myocardial infraction. The rationale of this study is to design and characterize an oral pulsatile drug delivery system containing pravastatin sodium, to modulate drug level in synchrony with the circadian rhythm of hypercholesterolemia. Various formulations have been made by varying the composition of pravastatin sodium with MCC, HPMC and the percentage release of the drug was analysed in each formulations. Drug-excipient possible interaction has been studied by FT-IR spectroscopic studies. The formulated tablets were evaluated by stability, friability, drug content uniformity tests.

Author(s): Sreeja Sreekumar G.

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