Development of Anti-Diarrhoeal Polyherbal Formulation “Antitrots”

Objective: The study evaluated the antidiarrhoeal activity of polyherbal formulation “antitrots” prepared in solution form by using the hydroalcoholic fruits extract of Phyllanthus emblica and Solanum nigrum against castor oil induced diarrhoea.
Materials and Methods: Polyherbal solution was formulated using fruits extract of both the plants with excipients and evaluated for physicochemical and antidiarrhoeal activity. The standard drug used for study was loperamide.
Results: The studies revealed that at dose of 200 mg/kg polyherbal formulation showed a considerable reduction of diarrhoea but at a dose of 400 mg/kg showed significant reduction of diarrhoea compared to vehicle control group when subjected to castor oil induced diarrhoea and intestinal motility model. Conclusion: The obtained results were nearly comparable with standard drug. Therefore the prepared formulation “antitrots” an effective antidiarrhoeal formulation.

Author(s): Rajput Rekha T., Gohil Kashmira J., Kumar Sourabh and Kumar Suneel

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