Development of analytical method for efavirenz by UV spectrophotometry using sodium hydroxide as solvent

The main aim of the present study is to develop a simple, sensitive, specific, spectrophotometric method developed for the detection of Efavirenz in bulk drug and pharmaceutical formulation. The optimum condition for the analysis of the drug was established. The wavelength (λmax) of the Efavirenz was found to be 267nm. The proposed method can be performed by using UV-Visible spectrophotometry using 0.5N NaOH as solvent. The regression coefficient of the linearity study was found to be 0.9918, and the slope of the linear is y=0.0738x. This method shows the linearity of 2 to 12μg/ml. Limit of detection was found to be 0.454μg/ml and the Limit of quantification was determined as the lowest concentration was found to be 1.499μg/ml. The proposed method will be suitable for the analysis of Efavirenz in bulk and pharmaceutical formulation

Author(s): Anton Smith. A, Maruthi. G, Velmurugan. A and Parimalakrishnan. S

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