Development of alginate gel beads-entrapped liposome for colon specific drug delivery of Prednisolone

Delivery of drugs to the systemic circulation through colonic absorption represents a novel mode of introducing peptide and protein drug molecules and drugs that absorb poorly from the upper gastrointestinal tract (GIT), as the colon lacks various digestive enzymes that are present in the upper GIT. Colon-specific drug delivery systems (CDDSs) can be used to improve the bioavailability of drugs given through the oral route. A novel formulation for oral administration using Eudragit S 100 coated calcium alginate gel beads-entrapped liposome and prednisolone as drug has been investigated for colon-specific drug delivery in vitro. Drug release studies were done in conditions mimicking stomach to colon transit. Result shows that the drug was protected from being released completely in the physiological environment of the stomach and small intestine. The release rate of prednisolone from the coated calcium alginate gel beads-entrapped liposome was dependent on the concentration of calcium and sodium alginate, the amount of prednisolone in the liposome, as well as the coating.. The colonic arrival time of the tablets is normally 4–5 h. The results clearly demonstrated that the coated calcium alginate gel beads entrapped liposome is a potential system for colon-specific drug delivery.

Author(s): Shammi Goyal, Hemraj Vashist, Avneet Gupta, Shammy Jindal and Amit Goyal

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