Develop a Simple RP-HPLC and UV-Visible Method for Estimation of Etoricoxib from Pharmaceutical Dosage

Objective: The main purpose of present study was to develop a validated and stable isocratic reverse phase high performance liquid chromatography and UV-Visible method for regulate the quality and estimation of Etoricoxib drug content from the marketed pharmaceutical tablets. Methods: The reverse phase high performance liquid chromatography and UV-Visible method validation for Etoricoxib have done followed by assay methodology. Results: The retention time (Rt) of Etoricoxib was 10.0 min with the flow rate of 1.0 mL/min at wave length 272 nm. The linearity of method was validated for Etoricoxib drug content in the range of 5-100 μg/mL with correlation coefficient (r) values 0.997 and 0.998 for RP-HPLC and UV-Visible, respectively. Conclusions: This method is stable and validated to assay analysis. Thus, the validated method is can be successfully applied to routine analysis for regulate the quality. It also should be used for analytical research purpose.

Author(s): Raju Chandra, Ashwani Sanghi, Deepak Kumar and Krishna Kumar Hindwan

Abstract | PDF

Share This Article