Design and synthesis of substituted clubbed triazolyl thiazole as
XDR and MDR antituberculosis agents

Dinkar Mundhe; A. V. Ch; ewar; Mahendra R. Shiradkar

Abstract

Design and synthesis of substituted clubbed triazolyl thiazole as XDR & MDR antituberculosis agents

The emergence of XDR & MDR tuberculosis have forced medicinal chemist to think out of the box to arrive at promising “Hit”. Here is the report which, suggest our attempt to discover a clubbed thiazolyl-triazole molecule that has shown potency almost comparable with isoniazid. Further evaluation with almost 25 XDR & MDR clinical isolates of tuberculosis suggest better profile of drug candidate than reference drug, isoniazid. The candidate is under further development status and is showing promising activity with lesser toxicity.

Author(s): Dinkar Mundhe , A. V. Chandewar, Mahendra R. Shiradkar

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