Design and evaluation of fast dissolving core tablets for press coating

The demand for Fast dissolving tablets has been growing during the last decade especially for elderly and children who have swallowing difficulties. Model drug is commonly used as non steroidal anti-inflammatory. Aceclofenac is used for the treatment of various types of Diseases Related to Arthritis. Formulation and evaluation of mouth dissolving tablet of Aceclofenac by using direct compression method. Formulation was carried out using different three types of super disintegrants (sodium starch glycolate, Crospovidone, Croscarmellose sodium) separately and in combination. The use of combination of superdisintergrants shows better result than the use of single superdisintergrants. In all formulations use of superdisintergrants was in same concentration i.e. (8mg) but the batch A1 was without superdisintergrants. The compatibility of the drug with the excipients was confirmed through FTIR studies. The effects of same concentrations of superdisintergrants on FDT of Aceclofenac were studies. It was found that Aceclofenac tablet passes not only preformulation parameter but also Weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time as well as in vitro dissolution. Among all of the batches the batch A6 shows better results than other batches.

Author(s): Jadhav S. B.and Kawtikwar P. S.

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