Cytotoxic activity of Euphorbia balsamifera with two new phenolic compounds

OBJECTIVES: The aim of the present study is to evaluate the biological activities of different extracts from the plant Euphorbia balsamifera and isolate and identify the active compounds in the plant.

METHODS: Dry samples of the aerial parts of Euphorbia balsamifera plant was extracted with hexane, ethyl acetate, chloroform, methanol/H2O, respectively to obtain different crude extracts with different polarity. cytotoxicity was performed for the plant fractions to isolate the most active constituents. Different chromatographic isolation from ethyl acetate fractions leads to isolation five compounds. The structure determination was accomplished by NMR spectroscopy and mass spectrometry. 

RESULTS: Two new phenolic compounds, 1-(4-(4-tert-butylphenoxy)-3,6-dihydroxy-2-methoxyphenyl) ethanone and 4-hydroxyphenethyl 4-hydroxybutanoate  were obtained with another three known compounds, 3β-cycloartanol,1-(2,4-dihydroxy-6-methoxyphenyl)ethenone and glutanol from ethyl acetate fraction.  cytotoxic activity against three cancer cell lines exhibited that chloroform fraction the most active fraction against HePG2 while hexane fraction exhibited to against MCF7 where the latex showed lowest activity against MCF7.

CONCLUSIONS:

The present study demonstrates that E. balsamifera plant extract/ fractions consider a promising plant that might be used in pharmaceutical industry.  

Author(s): Samirah M. Alsawqaee

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